Welcome to the Cogent HPLC Columns page.
We understand the critical role that High-Performance Liquid Chromatography (HPLC) columns play in your analytical processes. Our columns are designed to deliver precision, reliability, and efficiency, making them the ideal choice for a wide range of applications. Whether you're involved in pharmaceutical research, environmental analysis, or any other field requiring high-quality chromatographic separations, Cogent HPLC columns are here to meet your needs.
Why Choose Cogent HPLC Columns?
1. Innovative Technology Cogent HPLC columns are crafted with advanced silica hydride particles and ligands, providing unique selectivity and rapid equilibration. This innovation ensures precise separation of closely related compounds, making our columns ideal for both polar and non-polar analytes.
2. Versatility Our columns are suitable for various chromatographic modes, including Reversed Phase (RP), Normal Phase (NP), Ion Exchange (IEX) and Aqueous Normal Phase (ANP). This versatility allows you to tackle a wide range of analytical challenges with confidence.
3. High Purity and Consistency Manufactured with high-purity silica and minimal metal content, Cogent columns offer consistent results and reproducibility. Each column undergoes rigorous testing to ensure it meets our stringent quality standards.
Key Factors to Consider When Selecting an HPLC Column
1. Separation Mode The separation mode determines how compounds are separated on the column. Common modes include:
Aqueous Normal Phase (ANP): The best choice for polar compounds when you want to use Reversed Phase solvent. Excellent for LCMS and LCMSMS.
Reversed Phase (RP): Ideal for non-polar or moderately polar compounds, using non-polar stationary phases like C18 or C8.
Normal Phase (NP): Suitable for polar compounds, using polar stationary phases.
Ion-Exchange: Best for separating charged compounds.
2. Analyte Characteristics Consider the chemical properties of your analytes, such as polarity, molecular weight, and charge. This will help you choose a column with the appropriate stationary phase and pore size.
3. Column Specifications Key specifications to look for include:
Particle Size: Smaller particles (e.g., 1.8μm) offer higher resolution but may require higher pressure.
Pore Size: Choose based on the size of your analytes; common sizes include 100Å for small molecules.
Column Dimensions: Length and diameter affect separation efficiency and analysis time.
4. Application Requirements Consider the specific requirements of your application, such as the need for high throughput, sensitivity, or robustness. Cogent offers a range of columns tailored to different applications, ensuring you find the perfect match.
5. Method Development and Support Effective method development is essential for optimal column performance. Cogent provides comprehensive technical support and resources to assist you in developing and optimizing your methods.
Explore Our Product Range
Cogent column brands - Click below for listings of phases by brands and different uses.
Cogent HPS™ base deactivated columns in a 5um particle size. Excellent peak shapes with traditional HPLC.
Cogent IEX™ for ion exchange chromatography on high purity silica columns for biological compounds and polar compounds.
Cogent NP™ for use in normal phase HPLC or with methanol, excellent for lipids, sugars, polar compounds and preparative HPLC. High purity silica based in many pore sizes.
Cogent RP™ our highest grade reversed phase HPLC columns, made with industry leading, high purity silica, with over 20 years of experience. Our most popular line of columns for traditional reversed phase applications. Available in many pore sizes, particle sizes and stationary phases.
Cogent Similars™ are economical, alternative HPLC columns that match leading USP legacy brands.
Cogent TYPE-C™ silica columns made with silica hydride for exquisite, peptide, polar & closely related compound separations. This, our flagship brand, offers different selectivity from any column on the market. The Diamond Hydride and Phenyl Hydride are leaders for simple and reliable polar compound analysis that is not a HILIC column. Other phases for unique selectivity are available including the Bidentate C18, UDC-Cholesterol and others.
Contact Us
Ready to elevate your chromatographic separations? Contact our technical team today to learn more about Cogent HPLC columns and find the perfect solution for your analytical needs.
Click HERE for more information "About Cogent HPLC columns".
Click HERE for listing of all Cogent columns by stationary phase.
