RSA – Reduced Surface Activity Glass VialsWho Should Buy RSA™ Vials & Inserts.
Made with a new patent pending, glass manufacturing process.
RSA Glass vials and inserts have reduced surface activity for basic compounds. This is due to the elimination of virtually all silanols (hydroxyl groups) that can have deleterious effects on your analytes and sample solutions.
RSA autosampler vials and glass inserts are not manufactured with coatings; but have significantly reduced silanols and surface ions on the glass surface normally produced during the manufacturing process. This lack of surface ions makes them an excellent choice for HPLC, LCMS, GC and GCMS applications when quantitation, reliability and accuracy are important.
With standard borosilicate glass vials and inserts sample diluents (such as water) can de-protonate the many surface hydroxyl groups; producing a negative charge on the glass wall. The “acidic” functionality of silanols has been known to cause adsorption of basic compounds, change the sample solution pH and/or hydrolyze susceptible compounds rendering them undetectable. With RSA Glass vials and inserts there is virtually no sample “loss to the vial” and no “pH shifting” making your analysis more reliable.
If you are working with low abundance basic samples with regular glass vials, it is very possible that some of your compounds could easily be adsorbed to the glass wall. This can change your quantitation or completely remove the compound from solution preventing injection and ultimately masking its detection and identification. With RSA Glass vials and inserts this will not occur if the adsorption is due to silanol interaction.
If you are working with sensitive compounds commonly found in natural products, biological samples or chemical synthesis, the glass wall could be a problem for basic compounds. With RSA glass vials this problem is eliminated.
If you are working with basic proteins that adsorb or are affected by silanols or normal glass siloxanes; RSA-Pro surface treated glass vials and inserts will be a good solution for you. If your proteins are sticking to the glass due to adsorption by the hydrophilic surface, RSA Glass provides an almost completely ion free and an even less adsorptive surface. The low adsorption performance of RSA-Pro glass & treatment over standard borosilicate silanized glass is far superior for proteins and peptides especially when comparing adsorption consistency from vial to vial, even in the same package.
RSA glass vials are batch tested for metals that may cause sample or diluent contamination. It has ULTRA low levels of sodium, calcium, aluminum and boron. Sodium and boron levels are 200 to 300 times less concentrated compared to leading manufacturers with calcium and aluminum almost non-detectable. QC testing is performed using ion selective electrode and water from the vials after a 4 hour "soak" time.
There is no significant cost increase for RSA Glass vials and inserts compared to "Certified" products on the market. RSA vials are QC tested to meet or exceed any commercially “certified” vial or insert. That is our promise.